ANALISI FARMACO-TOSSICOLOGICA

Descrizione dell'attività di ricerca:

Il gruppo di ricerca si occupa di sviluppo, convalida ed applicazione di procedure originali per il campionamento, il pretrattamento e l’analisi strumentale di diverse sostanze bioattive.  L'attività di ricerca si esplica in cinque filoni principali:

1. Monitoraggio terapeutico di farmaci del Sistema Nervoso Centrale;

2. Estrazione ed analisi di principi attivi di origine vegetale;

3. Sviluppo di metodi analitici per ormoni, neurotrasmettitori, metaboliti, droghe d'abuso, sostanze dopanti in fluidi biologici;

4. Controllo di qualità di formulazioni farmaceutiche; 5. Altri metodi analitici.

Settori ERC (European Research Council):

PE4_3 Spectroscopic and spectrometric techniques

PE4_6 Analytical chemistry

PE4_8 Chemical instrumentation

PE4_11 Method development in chemistry

LS5_12 Psychiatric disorders

LS7_3 Pharmacology, pharmacogenomics, drug discovery and design, drug therapy

LS7_5 Toxicology

LS9_5 Agriculture related to crop production, soil biology and cultivation, applied plant biology

LS9_6 Food sciences

Responsabile scientifico/Coordinatore - Roberto Mandrioli (Professore associato, Dipartimento QuVi)

Collaborazioni nazionali e internazionali:

• Istituto di Metodologie Chimiche, CNR, Roma
• Institute for Analytical Chemistry, Università di Vienna
• Dipartimento di Scienze della Vita, Università di Modena e Reggio Emilia
• Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia
• Dipartimento Politiche Antidroga, Presidenza del Consiglio dei Ministri

Produzione scientifica:

• Roberto Mandrioli, Michele Protti, Laura Mercolini
  Evaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder
  Expert Opinion on Drug Metabolism and Toxicology, 11(1), 149-174 (2015)
  DOI: 10.1517/17425255.2015.991713
  IF = 2.598
• Roberto Mandrioli, Laura Mercolini
  Discontinued anxiolytic drugs (2009-2014)
  Expert Opinion on Investigational Drugs, 24(4), 557-573 (2015)
  DOI: 10.1517/13543784.2014.998335
  IF = 4.408
• Roberto Mandrioli, Michele Protti, Laura Mercolini
  Novel atypical antipsychotics: metabolism and Therapeutic Drug Monitoring (TDM)
  Current Drug Metabolism, 16(2), 141-151 (2015)
  DOI: 10.2174/1389200216666150602145005
  IF = 2.847
• Boaz Gedaliahu Samolsky Dekel, Gabriele Donati, Alessio Vasarri, Anna Laura Croci Chiocchini, Alberto Gori, Giuseppe Cavallari, Gianfranco Di Nino, Laura Mercolini, Michele Protti, Roberto Mandrioli, Rita Maria Melotti, Gaetano La Manna
  Dialyzability of oxycodone and its metabolites in chronic noncancer pain patients with end-stage renal disease
  Pain Practice, 17(5), 604-615 (2017)
  DOI: 10.1111/papr.12483
  IF = 2.187
• Michele Protti, Isacco Gualandi, Roberto Mandrioli, Sergio Zappoli, Domenica Tonelli, Laura Mercolini
  Analytical profiling of selected antioxidants and total antioxidant capacity of goji (Lycium ) berries
  Journal of Pharmaceutical and Biomedical Analysis, 143, 252-260 (2017)
  DOI: 10.1016/j.jpba.2017.05.048
  IF = 2.831
• Roberto Mandrioli, Laura Mercolini
  Metabolism of drugs used in the therapy of seizures: an analytical point of view. Part 1
  Current Drug Metabolism, 18(8), 735-756 (2017)
  DOI: 10.2174/1389200218666170406115350
  IF = 2.655
• Fabiana Antognoni, Roberto Mandrioli, Alessandra Bordoni, Mattia Di Nunzio, Blanca Viadel, Elisa Gallego, María Paz Villalba, Lidia Tomás-Cobos, Danielle Laure Taneyo Saa, Andrea Gianotti
  Integrated evaluation of the potential health benefits of einkorn-based breads
  Nutrients, 9, 1232-1248 (2017)
  DOI: 10.3390/nu9111232
  IF = 4.196
• Michele Protti, Maria Carmen Catapano, Boaz Gedaliahu Samolsky Dekel, James Rudge, Gilberto Gerra, Lorenzo Somaini, Roberto Mandrioli, Laura Mercolini
  Determination of oxycodone and its major metabolites in haematic and urinary matrices: comparison of traditional and miniaturised sampling approaches
  Journal of Pharmaceutical and Biomedical Analysis, 152, 204-214 (2018)
  DOI: 10.1016/j.jpba.2018.01.043
  IF 2017 = 2.831
• Roberto Mandrioli, Michele Protti, Laura Mercolini
  New-generation, non-SSRI antidepressants: Therapeutic Drug Monitoring and pharmacological interactions. Part 1: SNRIs, SMSs, SARIs
  Current Medicinal Chemistry, 25(7), 772-792 (2018)
  DOI: 10.2174/0929867324666170712165042
  IF 2017 = 469
• Michele Protti, Alice Vignali, Teresa Sanchez Blanco, James Rudge, Francesca Bugamelli, Anna Ferranti, Roberto Mandrioli, Laura Mercolini
  Enantioseparation and determination of asenapine in biological fluid micromatrices by HPLC with diode array detection
  Journal of Separation Science, 41(6), 1257-1265 (2018)
  DOI: 10.1002/jssc.201701315
  IF 2017 = 415
• Laura Mercolini, Roberto Mandrioli, Michele Protti
  Tutorial: volumetric absorptive microsampling (VAMS)
  Analytica Chimica Acta, 1046, 32-47 (2019)
  DOI: 1016/j.aca.2018.09.004
  IF 2017 = 5.123
• Michele Protti, Roberto Mandrioli, Laura Mercolini
  New strategies for anti-doping analysis
  Bioanalysis, 11(3),149-152 (2019)
  DOI: 10.4155/bio-2018-0290
  IF 2017 = 2.478 
• Fabiana Antognoni, Roberto Mandrioli, Giulia Potente, Danielle Laure Taneyo Saa, Andrea Gianotti
  Changes in carotenoids, phenolic acids and antioxidant capacity in bread wheat doughs fermented with different lactic acid bacteria strains (short communication)
  Food Chemistry, 292, 211-216 (2019)
  DOI: 10.1016/j.foodchem.2019.04.061
  IF 2017 = 4.946
• Irvin Tubon Usca, Augusta Zannoni, Chiara Bernardini, Roberta Salaroli, Martina Bertocchi, Roberto Mandrioli, Diego Vinueza, Fabiana Antognoni, Monica Forni
  In vitro anti-inflammatory effect of Salvia sagittata ethanolic extract on primary cultures of porcine aortic endothelial cells
  Oxidative Medicine and Cellular Longevity, 2019, Article ID 6829173, 11 pages (2019)
  DOI: 10.1155/2019/6829173
  IF 2017 = 4.936
• Michele Protti, Manuela Mandrone, Roberto Mandrioli, Concettina Cappadone, Giovanna Farruggia, Ilaria Chiocchio, Emil Malucelli, Gloria Isani, Ferruccio Poli, Laura Mercolini
  Analysis of Artemisia annua extracts and related products by high performance liquid chromatography-tandem mass spectrometry coupled to sample treatment miniaturization
  Journal of Pharmaceutical and Biomedical Analysis, 174, 81-88 (2019)
  DOI: 1016/j.jpba.2019.05.044
  IF 2017 = 2.831