ANALISI FARMACO-TOSSICOLOGICA

Analisi farmaceutica, nutraceutica, fitochimica e tossicologica

Descrizione dell'attività di ricerca:

Il gruppo di ricerca si occupa di sviluppo, convalida ed applicazione di procedure originali per il campionamento, il pretrattamento e l’analisi strumentale di diverse sostanze bioattive.  L'attività di ricerca si esplica in cinque filoni principali:

1. Monitoraggio terapeutico di farmaci del Sistema Nervoso Centrale;

2. Estrazione ed analisi di principi attivi di origine vegetale;

3. Sviluppo di metodi analitici per ormoni, neurotrasmettitori, metaboliti, droghe d'abuso, sostanze dopanti in fluidi biologici;

4. Controllo di qualità di formulazioni farmaceutiche; 5. Altri metodi analitici.

Settori ERC (European Research Council):

PE4_3 Spectroscopic and spectrometric techniques

PE4_6 Analytical chemistry

PE4_8 Chemical instrumentation

PE4_11 Method development in chemistry

LS5_12 Psychiatric disorders

LS7_3 Pharmacology, pharmacogenomics, drug discovery and design, drug therapy

LS7_5 Toxicology

LS9_5 Agriculture related to crop production, soil biology and cultivation, applied plant biology

LS9_6 Food sciences

Responsabile scientifico/Coordinatore - Roberto Mandrioli (Professore associato, Dipartimento QuVi)

Collaborazioni nazionali e internazionali:

  • Istituto di Metodologie Chimiche, CNR, Roma
  • Institute for Analytical Chemistry, Università di Vienna
  • Dipartimento di Scienze della Vita, Università di Modena e Reggio Emilia
  • Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia
  • Dipartimento Politiche Antidroga, Presidenza del Consiglio dei Ministri

Produzione scientifica:

  • Roberto Mandrioli, Michele Protti, Laura Mercolini
    Evaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder
    Expert Opinion on Drug Metabolism and Toxicology, 11(1), 149-174 (2015)
    DOI: 10.1517/17425255.2015.991713
    IF = 2.598
  • Roberto Mandrioli, Laura Mercolini
    Discontinued anxiolytic drugs (2009-2014)
    Expert Opinion on Investigational Drugs, 24(4), 557-573 (2015)
    DOI: 10.1517/13543784.2014.998335
    IF = 4.408
  • Roberto Mandrioli, Michele Protti, Laura Mercolini
    Novel atypical antipsychotics: metabolism and Therapeutic Drug Monitoring (TDM)
    Current Drug Metabolism, 16(2), 141-151 (2015)
    DOI: 10.2174/1389200216666150602145005
    IF = 2.847
  • Boaz Gedaliahu Samolsky Dekel, Gabriele Donati, Alessio Vasarri, Anna Laura Croci Chiocchini, Alberto Gori, Giuseppe Cavallari, Gianfranco Di Nino, Laura Mercolini, Michele Protti, Roberto Mandrioli, Rita Maria Melotti, Gaetano La Manna
    Dialyzability of oxycodone and its metabolites in chronic noncancer pain patients with end-stage renal disease
    Pain Practice, 17(5), 604-615 (2017)
    DOI: 10.1111/papr.12483
    IF = 2.187
  • Michele Protti, Isacco Gualandi, Roberto Mandrioli, Sergio Zappoli, Domenica Tonelli, Laura Mercolini
    Analytical profiling of selected antioxidants and total antioxidant capacity of goji (Lycium ) berries
    Journal of Pharmaceutical and Biomedical Analysis, 143, 252-260 (2017)
    DOI: 10.1016/j.jpba.2017.05.048
    IF = 2.831
  • Roberto Mandrioli, Laura Mercolini
    Metabolism of drugs used in the therapy of seizures: an analytical point of view. Part 1
    Current Drug Metabolism, 18(8), 735-756 (2017)
    DOI: 10.2174/1389200218666170406115350
    IF = 2.655
  • Fabiana Antognoni, Roberto Mandrioli, Alessandra Bordoni, Mattia Di Nunzio, Blanca Viadel, Elisa Gallego, María Paz Villalba, Lidia Tomás-Cobos, Danielle Laure Taneyo Saa, Andrea Gianotti
    Integrated evaluation of the potential health benefits of einkorn-based breads
    Nutrients, 9, 1232-1248 (2017)
    DOI: 10.3390/nu9111232
    IF = 4.196
  • Michele Protti, Maria Carmen Catapano, Boaz Gedaliahu Samolsky Dekel, James Rudge, Gilberto Gerra, Lorenzo Somaini, Roberto Mandrioli, Laura Mercolini
    Determination of oxycodone and its major metabolites in haematic and urinary matrices: comparison of traditional and miniaturised sampling approaches
    Journal of Pharmaceutical and Biomedical Analysis, 152, 204-214 (2018)
    DOI: 10.1016/j.jpba.2018.01.043
    IF 2017 = 2.831
  • Roberto Mandrioli, Michele Protti, Laura Mercolini
    New-generation, non-SSRI antidepressants: Therapeutic Drug Monitoring and pharmacological interactions. Part 1: SNRIs, SMSs, SARIs
    Current Medicinal Chemistry, 25(7), 772-792 (2018)
    DOI: 10.2174/0929867324666170712165042
    IF 2017 = 469
  • Michele Protti, Alice Vignali, Teresa Sanchez Blanco, James Rudge, Francesca Bugamelli, Anna Ferranti, Roberto Mandrioli, Laura Mercolini
    Enantioseparation and determination of asenapine in biological fluid micromatrices by HPLC with diode array detection
    Journal of Separation Science, 41(6), 1257-1265 (2018)
    DOI: 10.1002/jssc.201701315
    IF 2017 = 415
  • Laura Mercolini, Roberto Mandrioli, Michele Protti
    Tutorial: volumetric absorptive microsampling (VAMS)
    Analytica Chimica Acta, 1046, 32-47 (2019)
    DOI: 1016/j.aca.2018.09.004
    IF 2017 = 5.123
  • Michele Protti, Roberto Mandrioli, Laura Mercolini
    New strategies for anti-doping analysis
    Bioanalysis, 11(3),149-152 (2019)
    DOI: 10.4155/bio-2018-0290
    IF 2017 = 2.478 
  • Fabiana Antognoni, Roberto Mandrioli, Giulia Potente, Danielle Laure Taneyo Saa, Andrea Gianotti
    Changes in carotenoids, phenolic acids and antioxidant capacity in bread wheat doughs fermented with different lactic acid bacteria strains (short communication)
    Food Chemistry, 292, 211-216 (2019)
    DOI: 10.1016/j.foodchem.2019.04.061
    IF 2017 = 4.946
  • Irvin Tubon Usca, Augusta Zannoni, Chiara Bernardini, Roberta Salaroli, Martina Bertocchi, Roberto Mandrioli, Diego Vinueza, Fabiana Antognoni, Monica Forni
    In vitro anti-inflammatory effect of Salvia sagittata ethanolic extract on primary cultures of porcine aortic endothelial cells
    Oxidative Medicine and Cellular Longevity, 2019, Article ID 6829173, 11 pages (2019)
    DOI: 10.1155/2019/6829173
    IF 2017 = 4.936
  • Michele Protti, Manuela Mandrone, Roberto Mandrioli, Concettina Cappadone, Giovanna Farruggia, Ilaria Chiocchio, Emil Malucelli, Gloria Isani, Ferruccio Poli, Laura Mercolini
    Analysis of Artemisia annua extracts and related products by high performance liquid chromatography-tandem mass spectrometry coupled to sample treatment miniaturization
    Journal of Pharmaceutical and Biomedical Analysis, 174, 81-88 (2019)
    DOI: 1016/j.jpba.2019.05.044
    IF 2017 = 2.831

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